The human GPCRome · high-fidelity atlas
Every human
G protein-coupled receptor
in one place.
805 receptors across every class — structures, ligand pharmacology with assay-level references, tissue expression, disease associations, and a transparent development-interest score. Explore the druggable frontier of human signalling.
RhodopsinSecretinAdhesionGlutamateFrizzledTaste 2Odorant (class I)Odorant (class II)Other
805
Receptors
1,513
3D structures
127,314
Ligands
173,948
Assay records
2,544
Diseases linked
433
Approved drugs
Structure
Experimental PDB structures and AlphaFold models, with an interactive 3D viewer and 2D snake-plot topology.
Pharmacology
Ligands typed by action — agonist, antagonist, partial, inverse, allosteric — with Ki/IC50/EC50 and source references.
Expression & disease
Tissue expression across 50 organs, mapped onto the body, plus scored disease associations from Open Targets.
Development interest
A transparent 0–100 score from literature, ligands, structures, drugs, and disease evidence — with the breakdown shown.
Composition
Receptors by class
Leaderboard