Citation & licenses
Helix7 integrates and redistributes data from established public resources. Each is credited below with its licence and required citation. Every receptor page also carries source links for the specific values it shows, so attribution travels with the data.
How to cite Helix7
Helix7: an integrated atlas of the human GPCRome. Dokholyan Laboratory, University of Virginia. Available at https://helix7.dokhlab.org.
Manuscript in preparation — update with the published reference and DOI on release.
Data sources & licences
Receptor list, classification hierarchy, sequences, experimental structures, orphan designations
Pándy-Szekeres G, et al. GPCRdb in 2023. Nucleic Acids Res. 2023;51(D1):D395–D402. link
Ligands typed by pharmacological action, affinities, and primary references
Harding SD, et al. The IUPHAR/BPS Guide to PHARMACOLOGY in 2024. Nucleic Acids Res. 2024;52(D1):D1438–D1449. link
Consensus tissue RNA expression (nTPM) across 50 tissues
Uhlén M, et al. Tissue-based map of the human proteome. Science. 2015;347(6220):1260419. link
Scored target–disease associations and target tractability
Ochoa D, et al. The next-generation Open Targets Platform. Nucleic Acids Res. 2023;51(D1):D1353–D1359. link
Quantitative ligand bioactivities (Ki/IC50/EC50/Kd) and compounds, target-mapped to human receptors
Zdrazil B, et al. The ChEMBL Database in 2023. Nucleic Acids Res. 2024;52(D1):D1180–D1192. link
Additional target-mapped bioassays and compounds, including deposited high-throughput screens
Kim S, et al. PubChem 2023 update. Nucleic Acids Res. 2023;51(D1):D1373–D1380. link
Literature counts for the development-interest score and the reference library
National Library of Medicine. PubMed. Bethesda (MD): NLM. link
Experimental 3D structure coordinates rendered in the viewer
Berman HM, et al. The Protein Data Bank. Nucleic Acids Res. 2000;28(1):235–242. link
Predicted structure models used when no experimental structure exists
Jumper J, et al. Highly accurate protein structure prediction with AlphaFold. Nature. 2021;596:583–589. link
Target Development Level (TDL) convention informing the illumination score
Kelleher KJ, et al. Pharos 2023. Nucleic Acids Res. 2023;51(D1):D1405–D1416. link
ShareAlike obligations
The following sources are licensed under CC BY-SA, which requires that any adaptation of their data be shared under the same terms and that they be attributed:
- IUPHAR/BPS Guide to PHARMACOLOGY
- Human Protein Atlas
- ChEMBL
- Pharos / TCRD
Helix7 complies by (1) attributing every source here and on each receptor page, (2) linking each value back to its origin, and (3) releasing the integrated resource under CC BY-SA 4.0. Data is used unmodified in substance — only reformatted and cross-linked — and is provided for research use, not clinical guidance.