LGR5
ATchemOrphanLGR5
Rhodopsin· Class A orphans· 907 aa
Development interest
31/ 100
Tchem
A potent ligand exists, but no approved drug.
2,493 refs·5 ligands·0 structures
Literature
×30%
Disease evidence
×15%
Ligands
×20%
Approved drugs
×20%
Structures
×15%
Signalling
Signal transduction
Primary G-protein coupling is not curated for LGR5 in Helix7. See GPCRdb couplings for transducer data on this receptor.
At a glance
Key facts
- Structures
- 0
- Distinct ligands
- 5
- Approved drugs
- 0
- Disease links
- 708
- Organ systems
- 9
- Citations
- 2,493
AdiposeCardiovascularDigestiveEndocrineImmuneIntegumentaryMusculoskeletalNervousReproductive
Sources & attribution
GPCRdbCC BY 4.0Human Protein AtlasCC BY-SA 4.0IUPHAR/BPS Guide to PHARMACOLOGYCC BY-SA 4.0ChEMBLCC BY-SA 4.0Open Targets PlatformCC0 1.0
Data redistributed under each source's licence. See Citation & licenses.