ACKR4
ATchemACKR4
Rhodopsin· Chemokine receptors· 350 aa
Development interest
21/ 100
Tchem
A potent ligand exists, but no approved drug.
66 refs·3 ligands·0 structures
Disease evidence
×15%
Literature
×30%
Ligands
×20%
Approved drugs
×20%
Structures
×15%
Signalling
Signal transduction
Primary G-protein transducer(s):
Gi/Goprimary
Canonical coupling; some receptors also signal through secondary transducers and β-arrestin. See GPCRdb couplings for full data.
At a glance
Key facts
- Structures
- 0
- Distinct ligands
- 3
- Approved drugs
- 0
- Disease links
- 116
- Organ systems
- 10
- Citations
- 66
AdiposeCardiovascularDigestiveEndocrineImmuneIntegumentaryMusculoskeletalReproductiveRespiratoryUrinary
Sources & attribution
GPCRdbCC BY 4.0Human Protein AtlasCC BY-SA 4.0IUPHAR/BPS Guide to PHARMACOLOGYCC BY-SA 4.0Open Targets PlatformCC0 1.0
Data redistributed under each source's licence. See Citation & licenses.